Physics of life - Can Physics Fully Explain Life?

Suresh Gurung
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The Core Question: Can Physics Fully Explain Life?


Some argue that physics should aim for a "theory of everything"—reducing all phenomena, including life, to fundamental particles and forces. But is that the right approach?

Fact: String theory won’t tell us why cells divide. Knowing every atom in DNA doesn’t fully explain evolution. Life operates at a macroscopic level, emerging from—but not entirely defined by—atomic interactions.

The Limits of Reductionism
Physics excels at breaking systems into simpler parts (e.g., atoms → quarks). But biology’s complexity demands a different lens.

Case in Point:

  • A neuron’s electrical signals rely on ion channels (physics), but consciousness isn’t just the sum of these signals.
  • The Second Law of Thermodynamics drives disorder, yet life maintains order—a paradox physics alone doesn’t resolve.

Key Insight:

  • Emergent properties (like intelligence) arise from interactions at higher levels.
  • Biology’s "rules" (e.g., natural selection) aren’t derivable solely from quantum mechanics.
  • Where Physics and Biology Collide (Successfully)

Physics does clarify foundational biological processes:

  • Molecular Machines
  • ATP synthase (a nanoscale motor) converts energy with ~100% efficiency—studied via thermodynamics.

Data Point: 
  • Cryo-EM imaging reveals its rotary mechanism, linking structure to function.
  • Protein Folding
  • Misfolded proteins cause diseases like Alzheimer’s.
  • Physics-based simulations (e.g., Folding@home) predict folding pathways.
  • Evolution’s Thermodynamics
  • Energy flow (sunlight → ecosystems) fuels life’s complexity, aligning with entropy principles.

The Bigger Picture: Time, Chaos, and Life
Arrow of Time: Life’s irreversibility (aging, reproduction) mirrors entropy’s one-way direction.

Randomness vs. Determinism: Mutations (random) meet natural selection (deterministic)—a duality physics frameworks struggle to unify.

The Frontier: Consciousness and the Universe

Can physics explain cognition? Competing views:

Yes: Neural networks follow physical laws.

No: Subjective experience ("qualia") transcends particle interactions.

Provocative Idea:
Our universe’s constants (e.g., gravity strength) permit life. Change one, and life vanishes—a clue that physics and biology are intertwined at cosmic scales.

The Takeaway: A Multilayered Approach
To understand life:

Accept multiple levels (quantum → cellular → organismal).

Use physics where it fits (molecular processes).

Recognize emergent laws (e.g., Darwinian evolution).

Final Thought:
Physics won’t replace biology—but by refining its tools (e.g., studying entropy in cells), it illuminates life’s deepest mechanisms.

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